Distance between geocaches

[Ewe&Me 21]

I am aware that geocaches must be at least 161 meters apart but I also read that if it’s a puzzle cache with nothing physical at the site it’s okay to have them closer.  Does this also apply to Multicaches where the first site doesn’t have a physical cache and the second site is much farther away?  

[+Lynx Humble 434]

That also applies for the multi-cache.

[Ewe&Me 21]

Thank you.