There are waypoint managers for MacOS listed here:http://www.geocaching.com/software/
I don't use any of them myself, so I can't comment. The last time I looked at the ones available for MacOS, none of them could handle corrected coordinates (e.g., puzzle solutions), so I use boulter's Geocaching Basecamp instead. It's essentially an online waypoint manager.
From the screenshot on the iCaching (version 3.0) app, it appears that it supports corrected coordinates now.
Yes that's right, from version 1.1 it supports corrected coordinates