I been really trying to dig around and find all the Mac GPS software out there (paricularly OS X native) and here's what I've come up with:
(NOTE: some of this I've used and some I haven't. For the one's I haven't used my synopsis of features might be a bit off but hopefully I'm not too far off). Feel free to add any I've missed!
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GPS Connect- (Free/donate)
Upload/download waypoints and routes to many models of GPSr. (**I have used this in the past: It's okay but the waypoint doesn't load with the geocache "chest" symbol)
http://www.chimoosoft.com/gpsconnect.html
Link2GPS- ($12 by itself or $25 bundled with TopoDraw and gpsWrite)
Upload and download of waypoints and routes. (**I'm currently using this as a program as a trial- It does use the geocache symbol on uploaded geocaching waypoints on GPSr :-)
http://www.hiketech.com
MacGPSbabel- (Free/donate)
Can convert many file formats to many other file formats. Upload and download to many GPSr
http://sourceforge.net/project/showfiles.php?group_id=58972
Magellan Waypoint Manager- (Free/donate)
Magellan specific upload and download of waypoints
http://www.studiosoich.com/MWM.html
MacSimpleGPS- (Free/donate)
for use with LOC files uploading and downloading to GPSr
http://www.macsimplegps.com
Terrabrowser- (Free/donate)
Manually input a coord to see on terraserver aerial photo and/or topo maps.
(**I've used this program may times: It's okay but it almost never loads all the panels of the photos/maps. It is very useful to find coords for points to calibrate park maps for use in other mapping programs like MacGPSpro or TopoDraw)
http://www.chimoosoft.com/terrabrowser.html
TopoDraw- ($12 by itself or $25 bundled with Link2GPS and gpsWrite)
Shows waypoints and routes on top of maps (you have to calibrate a map or load one already calibrated by someone else because it doesn't come with any). Must use Link2GPS to download/upload GPSr waypoints and routes. (**I did successfully calibate a map with this program but could not figure out how to load a map calibrated by someone else for ExpertGPS)
http://www.hiketech.com
MacGPSpro- ($39)
Upload and download waypoints and routes to/from GPSr and show on topo maps (you have to load maps from various sources because it doesn't come with any). (**I bought this program but didn't figure out how to load maps and gave up- needs better documentation but you can often get answers via email)
http://www.macgpspro.com
GPSy (must use Classic mode)- (GPSy is Free, but Pro is $50)
Shows realtime data if connected to GPSr. Can load maps from various sources. Upload/download waypoints and routes. Text-to-speech of navigation data. Plus other features. Improved nautical stuff in Pro version. (**I haven't used this)
http://www.gpsy.com
Route66 USA for Mac- ($39)
Can plot position realtime when connected to GPSr. Very detailed road maps. Upload and download waypoints and routes to GPSr. (**I haven't used this myself but I've heard it takes up A LOT of room on the hard drive- Gigabytes)
http://www.66.com/route66
National Geographic State TOPOs- ($99 per state)
Upload and download waypoints and routes to/from GPSr and show on their own detailed topo maps.
http://www.ngmapstore.com/shopping/product...&iProductID=346
CacheMate- ($7)
Have a Palm and want to go paperless? This'll do it. (**This is what I use and recommend)
http://www.smittyware.com/palm/cachemate/
MacCMConvert- (Free/donate)
Converts GPX files to Upload to PDA and use with CacheMate. (**This is what I use and recommend)
http://www.jfatherton.co.uk/MacCMConvert