I just purchased the new Garmin StreetPilot 7500 for my vehicle. I should be getting it next week!
I bought it because I travel frequently during the spring and summer months, and I've wanted a unit just for the car, so I can easily locate restaurants, gas stations, and hotels when I'm traveling out of state. The unit is also equipped with traffic, weather, and XM Satellite Radio. Buying the unit, GXM 30 antenna, and bag to keep the unit in, I saved nearly $700 if I would've bought the unit alone at retail price, so I got a deal out of it.
I know the unit was designed with larger vehicles such as RV's, buses, etc. in mind, but I read a review that it can be used for those who like the larger screen size.