I got the native WherigoBuilder running on Pop!_OS 22.04. Here's how I did it: Update the default wine in the ubuntu packages to version 8.0 using this guide Update winetricks: sudo winetricks --self-update Create a new Wine environment using winetricks, using 32 bit architecture (or with the following command) WINEPREFIX="~/.local/share/wineprefixes/Wherigo-builder" WINEARCH="win32" winecfg Download the WherigoBuilder Install .NET 4.8 using winetricks (GU