I have a new 60Cx updated to 2.50 firmware and am running Windows 2000 Pro SP4 on Virtual PC 7.02 on a Quad G5 running Tiger 10.4.4.
I am using version 2.1 of the Garmin USB drivers, and the latest version of Mapsource.
Mapsource happily reads and writes tracks, waypoints and routes from the GPSr over USB. POI loader also works without problems.
Mapsource fails when trying to write maps direct to the unit, but will happily write these to a memory card in a USB card reader.
Also, I am fairly optimistic, given Garmin's policy so far on software support, that the forthcoming OSX version of Mapsource may be a free upgrade.