Lee, this thread was extremely helpful and I thank you for starting it. (In fact I joined this site based upon a google search on this topic.)
I was having difficulty registering a SD card (PNY 1GB). What finally ended up working was plugging in the LEI 2.0 reader, but also my SANDISK multi-card reader. I could register using the drive referenced in the SANDISK.
Now if I could figure out how to apply the firmware patch on my H2O C I could read the Navionics card I just spent $199 on... Waiting for Lowrance tech support to get back to me since I get a "signal error" when loading the update.
BTW, I want to use this for fishing trips I take to plot where I've been. Worked great out in the FL gulf last weekend. The content in Mapcreate 6 was accurate for the ICW markers and even wrecks and sandbars. Pretty cool.