Hi Tom,
I have a V, but not a Mac, so I may be guessing a bit here, but 3 things come to mind:
1. Have you tried the Auto Detect option when downloading? That should take the guesswork out of the settings on the Mac side.
2. Make certain you have not changed the comm settings on the V. The defaults are listed in the manual.
3. I assume that you are using Mapsource in some kind of Windows compatability mode. Serial communications used to be a problem with compatability software. Perhaps this is still the case. I would Google this sort of problem to determine if perhaps the issue is with the Mac.
Rick