I found it by doing some searching on another forum. I can't believe I didn't try this earlier.
Here is how you can hide all Navigator/Metroguide/Topo mapsets as a whole and not going through each mapset individually:
Main Menu, Setup, Map, Map Setup Information, then press Menu button.
There should be options to Show/Hide each map set.
From the map page:
Menu button, Set up Map, Map Setup Information, then press Menu button.